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10.1007/s11357-011-9309-2 145 HiranoA.YumimotoK.TsunematsuR.MatsumotoM.OyamaM.Kozuka-HataH.et al (2013)

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Nakagoe T, Sawai T, Tsuji T, et al

Autophagy enhanced by curcumin ameliorates inflammation in atherogenesis via the TFEB-P300-BRD4 axis

This makes them better for controlled research

The Febuxostat for Cerebral and CARdiorenovascular Events PrEvEntion StuDy (FREED) assigned 1,070 elderly patients with hyperuricemia to receive febuxostat or not (no febuxostat arm)